Bionanoscience for Innovative Global Healthcare Research & Technology (BIGHEART)
1/28/2013, 3:30 pm - 4:30 pm
Presenters: Luke P. Lee, Arnold and Barbara Silverman Distinguished Professor, Institute of Quantitative Biosciences, Department of Bioengineering and Biophysics Program, University of California, Berkeley
In the first part of talk, I will present biophotonic nano-satellites that have multiple functions: targeting, imaging, gene delivery & regulations in living systems. For the remote optical control of gene regulations and therapeutic applications, we have developed Oligonucleotides on a Nanoplasmonic Carrier Optical Switch (ONCOS). We also accomplished photonic gene circuits that utilized RNA-medicated gene silencing to multistep bidirectional control of specific gene expression by taking advantage of the tunability of the longitudinal plasmon resonance wavelength in gold optical nanoantennas.
In the second part of talk, I will discuss (1) cellular BASICs (Biologic Application Specific Integrated Circuits) for single stem cell analysis, dynamic cell culture array, and self-powered integrated microfluidic blood analysis system; (2) Biologically inspired 3D tissue chips: disease-specific integrated microphysiological human tissue models via normal and patient-specific human induced pluripotent stem cells for drug development and safety; (3) Integrated Molecular Diagnostic Systems (iMDx) for global healthcare. In summary, I will share my vision for the convergence of science, engineering, and medicine to transform life sciences, and finding the solutions for preventive personalized medicine and low-cost healthcare systems.