The Department of Microbiology & Immunology Seminar Series: Matthew J. Tyska
11/10/2009
3:00 pm
- 4:00 pm
Contact:
Location:
Medical Research Building III (Biological Sciences/Medical Research) Room 1220
Category:
Open to the Public
Matthew J. Tyska, Ph.D.
Assistant Professor, Department of Cell and Developmental Biology
Vanderbilt University Medical Center
"Microvillar membrane shedding: a novel facet of intestinal barrier function"
The brush border is an array of actin-rich microvilli that extend from the enterocyte apical surface. Within microvilli, the motor protein myosin-1a links the inner leaflet of the plasma membrane to a supporting parallel bundle of actin filaments. Although the functional consequence of myosin-1a/membrane interactions remained unclear for many years, our recent studies indicate that this motor can power the tip-ward movement of microvillar membrane along core actin bundles. This novel form of subcellular motility leads to the -shedding- of small vesicles from microvillar tips, into the intestinal lumen. Careful analysis of vesicle components suggests that shedding activity may represent a previously unidentified aspect of epithelial cell biology, which serves to protect enterocytes from microbes in the intestinal lumen.
Assistant Professor, Department of Cell and Developmental Biology
Vanderbilt University Medical Center
"Microvillar membrane shedding: a novel facet of intestinal barrier function"
The brush border is an array of actin-rich microvilli that extend from the enterocyte apical surface. Within microvilli, the motor protein myosin-1a links the inner leaflet of the plasma membrane to a supporting parallel bundle of actin filaments. Although the functional consequence of myosin-1a/membrane interactions remained unclear for many years, our recent studies indicate that this motor can power the tip-ward movement of microvillar membrane along core actin bundles. This novel form of subcellular motility leads to the -shedding- of small vesicles from microvillar tips, into the intestinal lumen. Careful analysis of vesicle components suggests that shedding activity may represent a previously unidentified aspect of epithelial cell biology, which serves to protect enterocytes from microbes in the intestinal lumen.